4th c. BC: Foundation of Anemurium
late 3rd c. BC: Possession of Ptolemy I
3rd-2nd c. BC: Seleucid Kingdom
late 1st c. BC: Semi-autonomous Kingdom of Cappadocia
early 1st c. AD: Direct subordination to Rome
38 AD: Ceded by Caligula to Antioch IV of Commagene
51-52 AD: Besieged by the people of Ketis – reinforcement of fortification
72 AD: Dethronement of Antioch IV by Vespasian – Anemurium under the Roman Empire
2nd-3rd c. AD: Imperial period
260 AD: Valerian is defeated by Sapor I – Arrival of the Sasanians in the area
382 AD: The fortification is strengthened by the first legion, the Armenian (Legio I Armeniaca)