920-922 (beginning): Emperor Romanos I founds the Myrelaion monastery and builds the katholikon.
922: Empress Theodora, wife of Romanos I is buried in Myrelaion.
931: The co-emperor Christophoros, eldest son of Romanos I is buried in Myrelaion.
946: Constantine, son of Romanos I, is buried in Myrelaion, in the same tomb with his wife Helena, who had died six years earlier.
948: Romanos’ remains are transferred to Myrelaio from the island of Prote.
961: Empress Helena, wife of Constantine VII Porphyrogennitos and daughter of Romanos I, is buried near her family in Myrelaion.
1059: Aikaterine, wife of Isaak I Komnenos and his daughter Maria retire to the Monastery of Myrelaion.
1087: Anna Dalassene offers Leros as a metochi to the Monastery of Myrelaion.
1203: The monastery of Myrelaion suffers extensive damage due to fire.
Ca. 1300: The church is repaired and restored. The substructure is converted to an underground temple for burial purposes; it is decorated with frescoes.
Before 1315: The Myrelaion becomes a male monastery.
End of 15th century: The grand vizier Mesih Ali Paşa, descended from the Palaiologos family, converts the Myrelaion church into a mosque, named Bodrum Camii ή Mesih Ali Paşa Camii.
1784: The Myrelaion is extensively damaged by fire. Repairs conducted in the north side of the building.
1911: Extensive damage from fire.
1930: D. Talbot-Rice and Th. Macridy excavate near the monument.
1964-5: The Archaeological Museum of Constantinople oversees the restoration work. Excavation and study of the monument by C. L. Striker. The restoration process continues until the 1980s.